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Issue 3, 2019
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Mechanisms of lipid extraction from skin lipid bilayers by sebum triglycerides

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Abstract

The skin surface, our first barrier against the external environment, is covered by the sebum oil, a lipid film composed of sebaceous and epidermal lipids, which is important in the regulation of the hydration level of our skin. Here, we investigate the pathways leading to the transfer of epidermal lipids from the skin lipid bilayer to the sebum. We show that the sebum triglycerides, a major component of sebum, interact strongly with the epidermal lipids and extract them from the bilayer. Using microsecond time scale molecular dynamics simulations, we identify and quantify the free energy associated with the skin lipid extraction process.

Graphical abstract: Mechanisms of lipid extraction from skin lipid bilayers by sebum triglycerides

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Publication details

The article was received on 09 Sep 2018, accepted on 09 Dec 2018 and first published on 17 Dec 2018


Article type: Paper
DOI: 10.1039/C8CP05706K
Citation: Phys. Chem. Chem. Phys., 2019,21, 1471-1477

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    Mechanisms of lipid extraction from skin lipid bilayers by sebum triglycerides

    A. S. Tascini, M. G. Noro, J. M. Seddon, R. Chen and F. Bresme, Phys. Chem. Chem. Phys., 2019, 21, 1471
    DOI: 10.1039/C8CP05706K

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