Issue 17, 2018

Halogen-like properties of the Al13 cluster mimicking astatine

Abstract

Astatine-211 is considered to be one of the most promising alpha-emitters in targeted alpha therapy (TAT). However, its development has been hindered by its not so well understood chemistry. Hence, any attempt to understanding it better is imperative. Here, we show through DFT calculations that the neutral endohedral Al13 cluster follows a reactivity pattern very similar to At, more than any other halogen. The halogen and alkali bonding with Al13 and At presented a strong similarity in their charge transfer processes. Moreover, upon the interchange of At with Al13, we found a stable configuration of the compound corresponding to the astatination of aryliodonium salts, which have been considered as possible precursors for the synthesis of 211At-labeled tracers. Our results provide promising proof of concept that the Al13 cluster mimics the behaviour of At and might help in better understanding its chemistry and in streamlining the chemical processes of radiolabeling biomolecules.

Graphical abstract: Halogen-like properties of the Al13 cluster mimicking astatine

Supplementary files

Article information

Article type
Communication
Submitted
23 Jan 2018
Accepted
04 Apr 2018
First published
04 Apr 2018

Phys. Chem. Chem. Phys., 2018,20, 11549-11553

Halogen-like properties of the Al13 cluster mimicking astatine

B. Molina, J. R. Soto and J. J. Castro, Phys. Chem. Chem. Phys., 2018, 20, 11549 DOI: 10.1039/C8CP00494C

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