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Issue 18, 2018
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Engineering l-asparaginase for spontaneous formation of calcium phosphate bioinspired microreactors

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Abstract

Active bioinspired materials are appealing biotechnological targets, and their study is gaining momentum. These materials, which comprise of an inorganic matrix and one or more biomolecules, are extremely variable and therefore may result difficult to characterize in their intimate structure. In this work we have prepared a hydroxyapatite–L-asparaginase composite, with the perspective of using it in acute leukemia treatment. We demonstrate that the use of electron microscopy and powder X-ray diffraction, combined with the atomic-resolution information coming from solid-state NMR, allows us to understand the topology of the material and how the different components interplay to obtain an active composite.

Graphical abstract: Engineering l-asparaginase for spontaneous formation of calcium phosphate bioinspired microreactors

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Supplementary files

Article information


Submitted
19 Jan 2018
Accepted
12 Mar 2018
First published
26 Apr 2018

This article is Open Access

Phys. Chem. Chem. Phys., 2018,20, 12719-12726
Article type
Paper

Engineering L-asparaginase for spontaneous formation of calcium phosphate bioinspired microreactors

A. Louka, I. Matlahov, S. Giuntini, L. Cerofolini, A. Cavallo, S. Pillozzi, E. Ravera, M. Fragai, A. Arcangeli, A. Ramamoorthy, G. Goobes and C. Luchinat, Phys. Chem. Chem. Phys., 2018, 20, 12719
DOI: 10.1039/C8CP00419F

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