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Issue 1, 2018
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Calcium-dependent hydrolysis of supported planar lipids was triggered by honey bee venom phospholipase A2 with the right orientation at the interface

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Abstract

Hydrolysis of planar phospholipids catalyzed by honey bee venom phospholipase A2 (bvPLA2) was studied. Experiments demonstrated that Ca2+ ions mediated between the lipids and bvPLA2, induced reorientation of bvPLA2, and activated hydrolysis. One of the hydrolysis products, fatty acids, was desorbed, and the other one, lysophospholipids, self-organized at the interface.

Graphical abstract: Calcium-dependent hydrolysis of supported planar lipids was triggered by honey bee venom phospholipase A2 with the right orientation at the interface

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Article information


Submitted
15 Sep 2017
Accepted
02 Nov 2017
First published
02 Nov 2017

Phys. Chem. Chem. Phys., 2018,20, 63-67
Article type
Paper

Calcium-dependent hydrolysis of supported planar lipids was triggered by honey bee venom phospholipase A2 with the right orientation at the interface

S. Kai, X. Li, B. Li, X. Han and X. Lu, Phys. Chem. Chem. Phys., 2018, 20, 63
DOI: 10.1039/C7CP06344J

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