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Issue 3, 2018
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Stable graphene oxide–gold nanoparticle platforms for biosensing applications

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Graphene oxide–gold nanoparticle (AuNPs@GO) hybrids were fabricated in water dispersions of graphene oxide (GO) and Au precursor completely free of stabilizing agents by UV-light irradiation. Gold nanoparticle (AuNP) nucleation, growth, and stabilization mechanisms at the surface of GO are discussed on the basis of UV-Vis, Raman, IR, and X-Ray photo-spectroscopy studies. The analyses of AuNPs@GO hybrids by transmission electron microscopy (TEM), thermogravimetric (TGA) and electrochemical tests show that they exhibit outstanding chemical, thermal and electrochemical stabilities. Thus, AuNPs@GO biosensing platforms were fabricated for surface enhanced Raman spectroscopy (SERS) detection of crystal violet (CV), a SERS standard molecule, and in a different set of experiments, for flavin adenine dinucleotide (FAD), a flavoprotein coenzyme that plays an important role in many oxidoreductase and reversible redox conversions in biochemical reactions. AuNPs@GO hybrids synthesized by using UV light irradiation show exceptional stability and high intensification of the Raman signals showing that they have high potential for use as biomedical probes for the detection, monitoring, and diagnosis of medical diseases.

Graphical abstract: Stable graphene oxide–gold nanoparticle platforms for biosensing applications

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Publication details

The article was received on 17 Jul 2017, accepted on 11 Dec 2017 and first published on 11 Dec 2017

Article type: Paper
DOI: 10.1039/C7CP04817C
Citation: Phys. Chem. Chem. Phys., 2018,20, 1685-1692
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    Stable graphene oxide–gold nanoparticle platforms for biosensing applications

    D. Hernández-Sánchez, G. Villabona-Leal, I. Saucedo-Orozco, V. Bracamonte, E. Pérez, C. Bittencourt and M. Quintana, Phys. Chem. Chem. Phys., 2018, 20, 1685
    DOI: 10.1039/C7CP04817C

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