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Issue 7, 2017
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Drug–DNA complexation as the key factor in photosensitized thymine dimerization

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Abstract

The crucial role of photosensitizer@DNA complexation in the formation of cyclobutane pyrimidine dimers (CPDs) has been demonstrated using femtosecond and nanosecond transient absorption and emission measurements in combination with in vitro DNA damage assays. This finding opens the door to re-evaluate the mechanisms involved in CPDs photosensitized by other chemicals.

Graphical abstract: Drug–DNA complexation as the key factor in photosensitized thymine dimerization

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Publication details

The article was received on 12 Dec 2016, accepted on 19 Jan 2017 and first published on 20 Jan 2017


Article type: Communication
DOI: 10.1039/C6CP08485K
Citation: Phys. Chem. Chem. Phys., 2017,19, 4951-4955

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    Drug–DNA complexation as the key factor in photosensitized thymine dimerization

    M. C. Cuquerella, V. Lhiaubet-Vallet, M. A. Miranda and F. Bosca, Phys. Chem. Chem. Phys., 2017, 19, 4951
    DOI: 10.1039/C6CP08485K

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