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Issue 18, 2016
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Propagation of the change in the membrane potential using a biocell-model

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Abstract

A new model system of nerve conduction, which has two sites (the potential-sending and the potential-receiving sites) was constructed by the use of some liquid-membrane cells which mimic the function of the K+ and Na+ channels. The model system setup was such that the membrane potential of the K+-channel cell (resting potential) was different from that of the Na+-channel cell (action potential). Initially, the K+-channel cell at the potential-sending site was connected to that at the potential-receiving site. After switching from the K+-channel cell to the Na+-channel cell at the potential-sending site, the membrane potential of the K+-channel cell at the potential-receiving site began to vary with the generation of the circulating current. By placing several K+-channel cells in parallel at the potential-receiving site, the propagation mechanism of the action potential was interpreted and the influence of the resistor and the capacitor on the propagation was evaluated.

Graphical abstract: Propagation of the change in the membrane potential using a biocell-model

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Publication details

The article was received on 03 Dec 2015, accepted on 31 Mar 2016 and first published on 31 Mar 2016


Article type: Paper
DOI: 10.1039/C5CP07446K
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Phys. Chem. Chem. Phys., 2016,18, 12689-12695

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    Propagation of the change in the membrane potential using a biocell-model

    Y. Takano, O. Shirai, Y. Kitazumi and K. Kano, Phys. Chem. Chem. Phys., 2016, 18, 12689
    DOI: 10.1039/C5CP07446K

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