Issue 10, 2016

Synthesis of magnetofluorescence Gd-doped CuInS2/ZnS quantum dots with enhanced longitudinal relaxivity

Abstract

In this paper, we describe the rapid microwave-assisted synthesis of Gd3+-doped CuInS2 (Gd:CIS) quaternary quantum dots (q-dots), which integrate the functions of optical fluorescence and magnetic resonance imaging. Through passivation of ZnS shells around Gd:CIS cores, high-quality and robust photostable Gd:CIS/ZnS core/shell q-dots with enhanced quantum yields were obtained. The intensity and peak-to-peak linewidth of the electron spin resonance (EPR) signal were found to vary depending on the Gd3+ concentration of Gd:CIS/ZnS. Benefiting from the incorporation of paramagnetic Gd3+ ions, the formed q-dots exhibited well-resolved and strong signals of electron paramagnetic resonance and provided significant contrast enhancement in T1-weighted images owing to the remarkably high longitudinal relaxivity (r1 = 55.90 mM−1 s−1) and low r2/r1 ratio (1.42), which are significantly higher than those of commercially available T1 contrast agents. We expect that this facile one-pot synthetic strategy can be extended to the preparation of other Cu-based sulfide quaternary nanomaterials.

Graphical abstract: Synthesis of magnetofluorescence Gd-doped CuInS2/ZnS quantum dots with enhanced longitudinal relaxivity

Supplementary files

Article information

Article type
Paper
Submitted
18 Nov 2015
Accepted
31 Jan 2016
First published
03 Feb 2016

Phys. Chem. Chem. Phys., 2016,18, 7132-7140

Author version available

Synthesis of magnetofluorescence Gd-doped CuInS2/ZnS quantum dots with enhanced longitudinal relaxivity

J. Chang, G. Chen and J. Li, Phys. Chem. Chem. Phys., 2016, 18, 7132 DOI: 10.1039/C5CP07063E

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