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Issue 39, 2015
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Structural self-organization of C60 and cisplatin in physiological solution

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Abstract

The specific features of structural self-organization of C60 fullerene and antitumor drug cisplatin (Cis) in physiological solution (0.9% NaCl) have been investigated by means of small-angle neutron scattering, scanning electron and atomic force microscopies, as well as isothermal titration calorimetry, dynamic light scattering and UV-Vis spectroscopy. The formation of C60 + Cis complexes, has been reported, unveiling the mechanism of medico-biological synergy observed during administration of the mixture of these drugs.

Graphical abstract: Structural self-organization of C60 and cisplatin in physiological solution

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Article information


Submitted
09 May 2015
Accepted
17 Aug 2015
First published
17 Sep 2015

Phys. Chem. Chem. Phys., 2015,17, 26084-26092
Article type
Paper

Structural self-organization of C60 and cisplatin in physiological solution

Yu. I. Prylutskyy, V. V. Cherepanov, M. P. Evstigneev, O. A. Kyzyma, V. I. Petrenko, V. I. Styopkin, L. A. Bulavin, N. A. Davidenko, D. Wyrzykowski, A. Woziwodzka, J. Piosik, R. Kaźmierkiewicz and U. Ritter, Phys. Chem. Chem. Phys., 2015, 17, 26084
DOI: 10.1039/C5CP02688A

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