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Issue 20, 2015
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Reaction-diffusion degradation model for delayed erosion of cross-linked polyanhydride biomaterials

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Abstract

We develop a theoretical model to explain the long induction interval of water intake that precedes the onset of erosion due to degradation caused by hydrolysis in the recently synthesized and studied cross-linked polyanhydrides. Various kinetic mechanisms are incorporated in the model in an attempt to explain the experimental data for the mass loss profile. Our key finding is that the observed long induction interval is attributable to the nonlinear dependence of the degradation rate constants on the local water concentration, which essentially amounts to the breakdown of the standard rate-equation approach, potential causes for which are then discussed. Our theoretical results offer physical insights into which microscopic studies will be required to supplement the presently available macroscopic mass-loss data in order to fully understand the origin of the observed behavior.

Graphical abstract: Reaction-diffusion degradation model for delayed erosion of cross-linked polyanhydride biomaterials

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Article information


Submitted
25 Jan 2015
Accepted
03 Mar 2015
First published
03 Mar 2015

Phys. Chem. Chem. Phys., 2015,17, 13215-13222
Article type
Paper
Author version available

Reaction-diffusion degradation model for delayed erosion of cross-linked polyanhydride biomaterials

S. Domanskyi, K. L. Poetz, D. A. Shipp and V. Privman, Phys. Chem. Chem. Phys., 2015, 17, 13215 DOI: 10.1039/C5CP00473J

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