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Issue 33, 2015
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Prospects for plasmonic hot spots in single molecule SERS towards the chemical imaging of live cells

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Abstract

Single molecule surface enhanced Raman scattering (SM-SERS) is a highly local effect occurring at sharp edges, interparticle junctions and crevices or other geometries with a sharp nanoroughness of plasmonic nanostructures (“hot spots”). The emission of an individual molecule at SM-SERS conditions depends on the local enhancement field of the hot spots, as well as the binding affinity and positioning at a hot spot region. In this regard, the stability of near-field nano-optics at hot spots is critical, particularly in a biological milieu. In this perspective review, we address recent advances in the experimental and theoretical approaches for the successful development of SM-SERS. Significant progress in the understanding of the interaction between the excitation electromagnetic field and the surface plasmon modes at the metallic or metallic/dielectric interface of various curvatures are described. New knowledge on methodological strategies for positioning the analytes for SM-SERS and Raman-assisted SERS or the SERS imaging of live cells has been acquired and displayed. In the framework of the extensive development of SM-SERS as an advancing diagnostic analytical technique, the real-time SERS chemical imaging of intracellular compartments and tracing of individual analytes has been achieved. In this context, we highlight the tremendous potential of SERS chemical imaging as a future prospect in SERS and SM-SERS for the prediction and diagnosis of diseases.

Graphical abstract: Prospects for plasmonic hot spots in single molecule SERS towards the chemical imaging of live cells

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Article information


Submitted
28 Oct 2014
Accepted
08 Jan 2015
First published
08 Jan 2015

This article is Open Access

Phys. Chem. Chem. Phys., 2015,17, 21072-21093
Article type
Perspective
Author version available

Prospects for plasmonic hot spots in single molecule SERS towards the chemical imaging of live cells

D. Radziuk and H. Moehwald, Phys. Chem. Chem. Phys., 2015, 17, 21072
DOI: 10.1039/C4CP04946B

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