Issue 26, 2013

Poly(propylene imine) dendrimer caps on mesoporous silicananoparticles for redox-responsive release: smaller is better

Abstract

To elucidate the importance of the size of capping agents in stimulus-induced release systems from mesoporous silica nanoparticles (MSNs), the effectiveness of poly(propylene imine) dendrimers in controlling the model drug release was studied. MCM-41-type MSNs were synthesized and characterized. Fluorescent compounds (fluorescein disodium salt and carboxyfluorescein) were loaded in the porous structure of the MSNs and entrapped in the silica matrix with the dendrimers of generations I through V by anchoring dendrimers on the MSN surface through disulfide bonds. Stimulus-induced release of the cargo was studied in the presence of dithiothreitol (DTT). Dendrimers of generations I and II were found to be more effective in model drug retention and subsequent release than higher generations. Moreover, MSNs modified with larger amounts of dendrimers lowered the cargo release in the presence of DTT. These findings are of importance for optimizing drug delivery systems based on responsive MSNs as they enable tuning of the amount of the released cargo by choosing the capping agent of appropriate size.

Graphical abstract: Poly(propylene imine) dendrimer caps on mesoporous silica nanoparticles for redox-responsive release: smaller is better

Supplementary files

Article information

Article type
Paper
Submitted
20 Dec 2012
Accepted
22 Apr 2013
First published
24 Apr 2013

Phys. Chem. Chem. Phys., 2013,15, 10740-10748

Poly(propylene imine) dendrimer caps on mesoporous silica nanoparticles for redox-responsive release: smaller is better

P. Nadrah, F. Porta, O. Planinšek, A. Kros and M. Gaberšček, Phys. Chem. Chem. Phys., 2013, 15, 10740 DOI: 10.1039/C3CP44614J

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