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Issue 3, 2013
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Effect of tension and curvature on the chemical potential of lipids in lipid aggregates

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Abstract

Understanding the factors that influence the free energy of lipids in bilayer membranes is an essential step toward understanding exchange processes of lipids between membranes. In general, both lipid composition and membrane geometry can affect lipid exchange rates between bilayer membranes. Here, the free energy change ΔGdes for the desorption of dipalmitoyl-phosphatidylcholine (DPPC) lipids from different lipid aggregates has been computed using molecular dynamics simulations and umbrella sampling. The value of ΔGdes is found to depend strongly on the local properties of the aggregate, in that both tension and curvature lead to an increase in ΔGdes. A detailed analysis shows that the increased desorption free energy for tense bilayers arises from the increased conformational entropy of the lipid tails, which reduces the favorable component −TΔSL of the desorption free energy.

Graphical abstract: Effect of tension and curvature on the chemical potential of lipids in lipid aggregates

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Publication details

The article was received on 29 Aug 2012, accepted on 14 Nov 2012 and first published on 15 Nov 2012


Article type: Paper
DOI: 10.1039/C2CP43018E
Phys. Chem. Chem. Phys., 2013,15, 876-881

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    Effect of tension and curvature on the chemical potential of lipids in lipid aggregates

    A. Grafmüller, R. Lipowsky and V. Knecht, Phys. Chem. Chem. Phys., 2013, 15, 876
    DOI: 10.1039/C2CP43018E

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