Issue 42, 2012
From the journal:

Physical Chemistry Chemical Physics

Interactions of marine-derived γ-pyrone natural products with phospholipid membranes†

Kimberley J. Powell,‡a   Pallavi Sharma,‡a   Joanna L. Richens,‡b   Benjamin M. Davis,b   John E. Moses*a  and  Paul O'Shea*b  

* Corresponding authors

a School of Chemistry, University of Nottingham, Nottingham, England, UK
E-mail: john.moses@nottingham.ac.uk

b Cell Biophysics Group, School of Biology, University of Nottingham, Nottingham, England, UK
E-mail: paul.oshea@nottingham.ac.uk

Abstract

The sacoglossan mollusc-derived metabolite, tridachiahydropyrone (3), and its proposed biosynthetic precursors (1 and 2) form part of a complex chemical defence system against predators and harmful UV light. Here, we provide supporting biophysical evidence that the metabolites become selectively localised at cell membranes and outline a binding scheme that accommodates the observed data. The possibility that localised lipid domains within the membrane have an effect on the localisation is also addressed.

Graphical abstract: Interactions of marine-derived γ-pyrone natural products with phospholipid membranes

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Article information

DOI
https://doi.org/10.1039/C2CP42920A
Article type
Communication
Submitted
20 Aug 2012
Accepted
18 Sep 2012
First published
02 Oct 2012

Phys. Chem. Chem. Phys., 2012,14, 14489-14491

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Interactions of marine-derived γ-pyrone natural products with phospholipid membranes

K. J. Powell, P. Sharma, J. L. Richens, B. M. Davis, J. E. Moses and P. O'Shea, Phys. Chem. Chem. Phys., 2012, 14, 14489 DOI: 10.1039/C2CP42920A

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