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Issue 16, 2012
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Energetics of ligand binding to the DNA minor groove

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Abstract

In the present work the decomposition of the total Gibbs free energy of ligand-DNA binding onto various physical terms was accomplished for the group of nine DNA minor groove binders (MGB ligands) differing in both structure and charge state. The decomposition protocol includes the analysis of the most complete set of physical factors known to contribute to the complexation process, viz. the net change in the number of degrees of freedom (translational, rotational, vibrations of the chemical bonds and vibrations of the ligand as a whole within the binding site), the conformational entropy, van der Waals, electrostatic and hydrophobic interactions, the polyelectrolyte contribution and the net effect of changes in the number of hydrogen bonds. All of these processes are further decomposed into the interaction with the solvent and the interaction of the ligand with DNA. The principal outcome of the decomposition is the possibility of performing a comparative analysis of the energetic contribution of various physical terms and provide an answer to the question concerning what physical factors stabilize or destabilize the complexes of MGB ligands with DNA.

Graphical abstract: Energetics of ligand binding to the DNA minor groove

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Publication details

The article was received on 18 Jan 2012, accepted on 17 Feb 2012 and first published on 21 Feb 2012


Article type: Paper
DOI: 10.1039/C2CP40182G
Citation: Phys. Chem. Chem. Phys., 2012,14, 5588-5600

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    Energetics of ligand binding to the DNA minor groove

    V. V. Kostjukov, A. A. H. Santiago, F. R. Rodriguez, S. R. Castilla, J. A. Parkinson and M. P. Evstigneev, Phys. Chem. Chem. Phys., 2012, 14, 5588
    DOI: 10.1039/C2CP40182G

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