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Issue 35, 2011
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Possible mechanism underlying high-pressure unfolding of proteins: formation of a short-period high-density hydration shell

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Abstract

Hydration effects on high-pressure unfolding of a hydrophobic polymer chain are investigated through a multiscale simulation based on density-functional theory. The results strongly suggest the following: a thermodynamic origin for high-pressure denaturation, i.e., the decrease in volume due to the unfolding can be explained by the formation of a short-period high-density hydration shell.

Graphical abstract: Possible mechanism underlying high-pressure unfolding of proteins: formation of a short-period high-density hydration shell

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Article information


Submitted
28 Apr 2011
Accepted
20 Jul 2011
First published
03 Aug 2011

Phys. Chem. Chem. Phys., 2011,13, 15829-15832
Article type
Communication

Possible mechanism underlying high-pressure unfolding of proteins: formation of a short-period high-density hydration shell

T. Sumi and H. Sekino, Phys. Chem. Chem. Phys., 2011, 13, 15829
DOI: 10.1039/C1CP21347D

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