Issue 24, 2011
From the journal:

Physical Chemistry Chemical Physics

Recent progress in SERS biosensing

Kyle C. Bantz,†a   Audrey F. Meyer,†a   Nathan J. Wittenberg,b   Hyungsoon Im,b   Özge Kurtuluş,a   Si Hoon Lee,c   Nathan C. Lindquist,b   Sang-Hyun Oh*bc  and  Christy L. Haynes*a  

* Corresponding authors

a Department of Chemistry, University of Minnesota, Twin Cities, USA
E-mail: chaynes@umn.edu

b Department of Electrical and Computer Engineering, University of Minnesota, Twin Cities, USA
E-mail: sang@umn.edu

c Department of Biomedical Engineering, University of Minnesota, Twin Cities, USA

Abstract

This perspective gives an overview of recent developments in surface-enhanced Raman scattering (SERS) for biosensing. We focus this review on SERS papers published in the last 10 years and to specific applications of detecting biological analytes. Both intrinsic and extrinsic SERS biosensing schemes have been employed to detect and identify small molecules, nucleic acids, lipids, peptides, and proteins, as well as for in vivo and cellular sensing. Current SERS substrate technologies along with a series of advancements in surface chemistry, sample preparation, intrinsic/extrinsic signal transduction schemes, and tip-enhanced Raman spectroscopy are discussed. The progress covered herein shows great promise for widespread adoption of SERS biosensing.

Graphical abstract: Recent progress in SERS biosensing

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Article information

DOI
https://doi.org/10.1039/C0CP01841D
Article type
Perspective
Submitted
16 Sep 2010
Accepted
28 Mar 2011
First published
21 Apr 2011

Phys. Chem. Chem. Phys., 2011,13, 11551-11567

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Recent progress in SERS biosensing

K. C. Bantz, A. F. Meyer, N. J. Wittenberg, H. Im, Ö. Kurtuluş, S. H. Lee, N. C. Lindquist, S. Oh and C. L. Haynes, Phys. Chem. Chem. Phys., 2011, 13, 11551 DOI: 10.1039/C0CP01841D

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