Issue 34, 2010
From the journal:

Physical Chemistry Chemical Physics

Microelectrode investigation of neuroneal ageing from a single identified neurone

Bhavik Anil Patel,ab   Martin Arundell,ab   Kim H. Parker,a   Mark S. Yeomanb  and  Danny O'Hare*a  

* Corresponding authors

a Department of Bioengineering, Imperial College London, London, UK
E-mail: d.ohare@imperial.ac.uk
Fax: +44 (0)207 5949817
Tel: +44 (0)207 5945173

b Centre for Biomedical and Health Sciences Research, Cockcroft Building, University of Brighton, Moulsecoomb, Brighton, East Sussex, UK

Abstract

Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamine neurotransmitter serotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.

Graphical abstract: Microelectrode investigation of neuroneal ageing from a single identified neurone

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Article information

DOI
https://doi.org/10.1039/C0CP00310G
Article type
Paper
Submitted
21 Apr 2010
Accepted
14 Jun 2010
First published
12 Jul 2010

Phys. Chem. Chem. Phys., 2010,12, 10065-10072

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Microelectrode investigation of neuroneal ageing from a single identified neurone

B. A. Patel, M. Arundell, K. H. Parker, M. S. Yeoman and D. O'Hare, Phys. Chem. Chem. Phys., 2010, 12, 10065 DOI: 10.1039/C0CP00310G

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