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Issue 22, 2010
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Prospects for sub-micron solid state nuclear magnetic resonance imaging with low-temperature dynamic nuclear polarization

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Abstract

We evaluate the feasibility of 1H nuclear magnetic resonance (NMR) imaging with sub-micron voxel dimensions using a combination of low temperatures and dynamic nuclear polarization (DNP). Experiments are performed on nitroxide-doped glycerolwater at 9.4 T and temperatures below 40 K, using a 30 mW tunable microwave source for DNP. With DNP at 7 K, a 0.5 μL sample yields a 1H NMR signal-to-noise ratio of 770 in two scans with pulsed spin-lock detection and after 80 db signal attenuation. With reasonable extrapolations, we infer that 1H NMR signals from 1 μm3 voxel volumes should be readily detectable, and voxels as small as 0.03 μm3 may eventually be detectable. Through homonuclear decoupling with a frequency-switched Lee–Goldburg spin echo technique, we obtain 830 Hz 1H NMR linewidths at low temperatures, implying that pulsed field gradients equal to 0.4 G/d or less would be required during spatial encoding dimensions of an imaging sequence, where d is the resolution in each dimension.

Graphical abstract: Prospects for sub-micron solid state nuclear magnetic resonance imaging with low-temperature dynamic nuclear polarization

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Article information


Submitted
08 Apr 2010
Accepted
05 May 2010
First published
11 May 2010

Phys. Chem. Chem. Phys., 2010,12, 5779-5785
Article type
Paper

Prospects for sub-micron solid state nuclear magnetic resonance imaging with low-temperature dynamic nuclear polarization

K. R. Thurber and R. Tycko, Phys. Chem. Chem. Phys., 2010, 12, 5779
DOI: 10.1039/C0CP00157K

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