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Issue 22, 2010
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Application of ex situ dynamic nuclear polarization in studying small molecules

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Abstract

Dynamic nuclear polarization (DNP) has become an attractive technique to boost the sensitivity of NMR experiments. In the case of ex situ polarizations two-dimensional (2D) spectra are limited by the short lifetime of the polarization after dissolution and sample transfer to a high field NMR magnet. This limitation can be overcome by various approaches. Here we show how the use of 13C-labelled acetyl tags can help to obtain 2D-HMQC spectra for many small molecules, owing to a nuclear Overhauser enhancement between 13C spins originating from the long-lived carbonyl carbon, which extends the lifetimes of other 13C spins with shorter longitudinal relaxation times. We also show an alternative approach of using an optimized polarization matrix.

Graphical abstract: Application of ex situ dynamic nuclear polarization in studying small molecules

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Article information


Submitted
08 Feb 2010
Accepted
23 Apr 2010
First published
10 May 2010

Phys. Chem. Chem. Phys., 2010,12, 5868-5871
Article type
Paper

Application of ex situ dynamic nuclear polarization in studying small molecules

C. Ludwig, I. Marin-Montesinos, M. G. Saunders, A. Emwas, Z. Pikramenou, S. P. Hammond and U. L. Günther, Phys. Chem. Chem. Phys., 2010, 12, 5868
DOI: 10.1039/C002700F

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