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Issue 35, 2010

Conformational behavior of fibrinogen on topographically modified polymer surfaces

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Abstract

The influence of topographical surface features at the submicron scale on the structural changes in the surface-adsorbed fibrinogen was investigated on poly(lactic-co-glycolic-acid) (PLGA) films. Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) was employed in this study for the induced conformational change of fibrinogen over various adsorption times, while the adsorption kinetics of fibrinogen was quantified by the enzyme linked immunosorbent assay (ELISA). When a PLGA surface is modified topographically, the adsorbed fibrinogen undergoes less conformational change when compared to adsorption on the pristine PLGA surface. The extent of conformational change is related to platelet adhesion. Reduced thrombogenicity was demonstrated by the higher ratios of α-helix to β-turn and β-sheet to β-turn structures on the topographic PLGA film, which suggests that topographical manipulation of surfaces is a viable approach to influence the thrombogenicity of surfaces.

Graphical abstract: Conformational behavior of fibrinogen on topographically modified polymer surfaces

Article information


Submitted
26 Jan 2010
Accepted
26 Apr 2010
First published
23 Jun 2010

Phys. Chem. Chem. Phys., 2010,12, 10301-10308
Article type
Paper

Conformational behavior of fibrinogen on topographically modified polymer surfaces

L. B. Koh, I. Rodriguez and S. S. Venkatraman, Phys. Chem. Chem. Phys., 2010, 12, 10301 DOI: 10.1039/C001747G

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