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Issue 3, 2020
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Plastically bendable pregabalin multi-component systems with improved tabletability and compressibility

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Abstract

Pregabalin is an anti-convulsant blockbuster chiral drug with the trade name Lyrica in its S-form. Anhydrous pregabalin (SPG) is brittle in nature and herein, we report two novel plastically bendable SPG salts with pharmaceutically acceptable coformers oxalic acid and salicylic acid. These mechanically flexible salts show improved solubility, tabletability and compressibility compared to the marketed anhydrous form.

Graphical abstract: Plastically bendable pregabalin multi-component systems with improved tabletability and compressibility

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Article information


Submitted
15 Oct 2019
Accepted
09 Dec 2019
First published
10 Dec 2019

CrystEngComm, 2020,22, 412-415
Article type
Communication

Plastically bendable pregabalin multi-component systems with improved tabletability and compressibility

U. B. R. Khandavilli, M. Yousuf, B. E. Schaller, R. R. E. Steendam, L. Keshavarz, P. McArdle and P. J. Frawley, CrystEngComm, 2020, 22, 412
DOI: 10.1039/C9CE01625B

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