Issue 28, 2019

Piroxicam–clonixin drug–drug cocrystal solvates with enhanced hydration stability

Abstract

Cocrystallisation of two non-steroidal anti-inflammatory drugs, piroxicam and clonixin, yielded eight drug–drug cocrystal solvates. Solvents having a moderate polarity are essential for the formation and stabilization of these crystalline complexes. The pharmaceutically acceptable ethyl acetate solvate demonstrated superior physical stability against hydration.

Graphical abstract: Piroxicam–clonixin drug–drug cocrystal solvates with enhanced hydration stability

Supplementary files

Article information

Article type
Communication
Submitted
01 May 2019
Accepted
20 Jun 2019
First published
20 Jun 2019

CrystEngComm, 2019,21, 4145-4149

Piroxicam–clonixin drug–drug cocrystal solvates with enhanced hydration stability

D. Li, J. Li, Z. Deng and H. Zhang, CrystEngComm, 2019, 21, 4145 DOI: 10.1039/C9CE00666D

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