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Issue 13, 2019
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High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media

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Abstract

2H-Benzo[d]1,2,3-triazole derivatives with a range of chemical functionalities showed significant organogel formation, particularly bis-amide derivative 4e which gave robust thermally stable gels, in a range of solvents down to 0.1 wt%. The gelators proved responsive under pH stimuli or to the presence of metal cations. The gels also proved to be useful vehicles to crystallize pharmaceutical drugs, resulting in a change in polymorphic outcome in the case of sulfathiazole compared to the solution crystallization outcome.

Graphical abstract: High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media

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Supplementary files

Article information


Submitted
12 Oct 2018
Accepted
27 Nov 2018
First published
27 Nov 2018

CrystEngComm, 2019,21, 2135-2143
Article type
Paper

High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media

I. Torres-Moya, B. Saikia, P. Prieto, J. R. Carrillo and J. W. Steed, CrystEngComm, 2019, 21, 2135
DOI: 10.1039/C8CE01742E

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