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Issue 18, 2016
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Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: a surface-mediated transformation

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Abstract

This work explores the mechanisms underlying the crystallization of citrate-functionalized amorphous calcium phosphate (cit-ACP) in two relevant media, combining in situ and ex situ characterization techniques. Results demonstrate that citrate desorption from cit-ACP triggers the surface-mediated transformation to nanocrystalline apatite (Ap). Our findings shed light on the key role of citrate, an important component of bone organic matrix, and the medium composition in controlling the rate of transformation and the morphology of the resulting Ap phase.

Graphical abstract: Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: a surface-mediated transformation

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Supplementary files

Article information


Submitted
06 Mar 2016
Accepted
05 Apr 2016
First published
07 Apr 2016

CrystEngComm, 2016,18, 3170-3173
Article type
Communication

Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: a surface-mediated transformation

K. Chatzipanagis, M. Iafisco, T. Roncal-Herrero, M. Bilton, A. Tampieri, R. Kröger and J. M. Delgado-López, CrystEngComm, 2016, 18, 3170
DOI: 10.1039/C6CE00521G

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