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Issue 26, 2016
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Anticancer activity of large metalla-assemblies built from half-sandwich complexes

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Abstract

A series of octanuclear p-cymene ruthenium and pentamethylcyclopentadienyl rhodium and iridium metalla-assemblies has been prepared from tetrapyridyl porphyrin (tpp) panels and the corresponding dinuclear clips, (η6-MeC6H4Pri)2Ru24-C6HRO4)Cl2 (R = C11H23) and (η5-C5Me5)2M24-C6HRO4)Cl2 (M = Rh, Ir). All complexes were isolated in good yield as their triflate salts, [(η6-MeC6H4Pri)8Ru84-tpp)24-C6HRO4)4][CF3SO3]8 (1), [(η5-C5Me5)8Rh84-tpp)24-C6HRO4)4][CF3SO3]8 (2) and [(η5-C5Me5)8Ir84-tpp)24-C6HRO4)4][CF3SO3]8 (3), and fully characterized by spectroscopic methods. The antiproliferative activity of the complexes was evaluated on the cancerous (MCF-7, B16 and A549) and non-cancerous (NIH 3T3) cell lines, showing in all cases IC50 values around 0.1 μM. Further biological studies suggest that apoptosis is induced by the complexes and that interaction with DNA can be in part responsible for the high cytotoxicity.

Graphical abstract: Anticancer activity of large metalla-assemblies built from half-sandwich complexes

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Supplementary files

Article information


Submitted
19 Jan 2016
Accepted
21 Feb 2016
First published
24 Feb 2016

CrystEngComm, 2016,18, 4952-4957
Article type
Paper

Anticancer activity of large metalla-assemblies built from half-sandwich complexes

G. Gupta, G. S. Oggu, N. Nagesh, K. K. Bokara and B. Therrien, CrystEngComm, 2016, 18, 4952
DOI: 10.1039/C6CE00139D

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