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Issue 44, 2014
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Halogen-bond driven co-crystallization of potential anti-cancer compounds: a structural study

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Abstract

The halogen-bonding ability of a series of bis-pyridine based pharmaceutically active ingredients is explored and the structural behaviour of co-crystals thereof is compared with that of their hydrogen-bonded analogues. All co-crystals are analysed using IR spectroscopy and thirteen new crystal structures comprising iodoperfluoroalkanes and bis-pyridineacetamides are presented. Binding preferences, structural patterns and correlations between molecular and crystal structures are discussed in the context of both hydrogen- and halogen bonds.

Graphical abstract: Halogen-bond driven co-crystallization of potential anti-cancer compounds: a structural study

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Article information


Submitted
04 Aug 2014
Accepted
19 Sep 2014
First published
03 Oct 2014

CrystEngComm, 2014,16, 10203-10209
Article type
Paper

Halogen-bond driven co-crystallization of potential anti-cancer compounds: a structural study

C. B. Aakeröy, D. Welideniya, J. Desper and C. Moore, CrystEngComm, 2014, 16, 10203
DOI: 10.1039/C4CE01614A

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