Issue 37, 2014
From the journal:

CrystEngComm

Capturing a novel metastable polymorph of the anticancer drug gefitinib†

Shridhar H. Thorat,a   Manjusha V. Patwadkar,b   Rajesh G. Gonnade*a  and  R. Vaidhyanathanc  

* Corresponding authors

a Center for Materials Characterization, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pashan, Pune, India

b Polymer Science and Engineering Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pashan, Pune, India
E-mail: rg.gonnade@ncl.res.in
Fax: +91 20 25902642
Tel: +91 20 25902225

c Department of Chemistry, Indian Institute of Science Education and Research, Pune, India
E-mail: vaidhya@iiserpune.ac.in
Tel: +91 20 25908073

Abstract

Gefitinib, a life-extending anticancer drug, exhibits solvent-mediated conformational polymorphism to yield stable (form I) and novel metastable (form II) polymorphs. Crystal structure analysis revealed 3D isostructurality in the molecular organization of the polymorphs, and the metastable polymorph undergoes a crystal-to-crystal thermal phase transition to the stable polymorph.

Graphical abstract: Capturing a novel metastable polymorph of the anticancer drug gefitinib

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Article information

DOI
https://doi.org/10.1039/C4CE01446D
Article type
Communication
Submitted
12 Jul 2014
Accepted
22 Jul 2014
First published
08 Aug 2014

CrystEngComm, 2014,16, 8638-8641

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Capturing a novel metastable polymorph of the anticancer drug gefitinib

S. H. Thorat, M. V. Patwadkar, R. G. Gonnade and R. Vaidhyanathan, CrystEngComm, 2014, 16, 8638 DOI: 10.1039/C4CE01446D

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