Jump to main content
Jump to site search

Issue 37, 2014
Previous Article Next Article

Capturing a novel metastable polymorph of the anticancer drug gefitinib

Author affiliations

Abstract

Gefitinib, a life-extending anticancer drug, exhibits solvent-mediated conformational polymorphism to yield stable (form I) and novel metastable (form II) polymorphs. Crystal structure analysis revealed 3D isostructurality in the molecular organization of the polymorphs, and the metastable polymorph undergoes a crystal-to-crystal thermal phase transition to the stable polymorph.

Graphical abstract: Capturing a novel metastable polymorph of the anticancer drug gefitinib

Back to tab navigation

Supplementary files

Article information


Submitted
12 Jul 2014
Accepted
22 Jul 2014
First published
08 Aug 2014

CrystEngComm, 2014,16, 8638-8641
Article type
Communication
Author version available

Capturing a novel metastable polymorph of the anticancer drug gefitinib

S. H. Thorat, M. V. Patwadkar, R. G. Gonnade and R. Vaidhyanathan, CrystEngComm, 2014, 16, 8638
DOI: 10.1039/C4CE01446D

Social activity

Search articles by author

Spotlight

Advertisements