Issue 44, 2014

Towards understanding P-gp resistance: a case study of the antitumour drug cabazitaxel

Abstract

A detailed structural study and Hirshfeld surface analysis of cabazitaxel in its anhydrous, hydrated and solvated forms have revealed that the three-dimensional architecture of the drug molecule is retained regardless of the crystalline environment. This prompted comparison with its taxane predecessors, suggesting key factors contributing to cabazitaxel's poor affinity to P-gp.

Graphical abstract: Towards understanding P-gp resistance: a case study of the antitumour drug cabazitaxel

Supplementary files

Article information

Article type
Communication
Submitted
24 Jun 2014
Accepted
01 Aug 2014
First published
01 Aug 2014

CrystEngComm, 2014,16, 10161-10164

Author version available

Towards understanding P-gp resistance: a case study of the antitumour drug cabazitaxel

U. Baisch and L. Vella-Zarb, CrystEngComm, 2014, 16, 10161 DOI: 10.1039/C4CE01279H

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