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Issue 5, 2012
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Controlled synthesis of luminescent F-substituted strontium hydroxyapatite with hierarchical structures for drug delivery

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Abstract

Fluorine substituted strontium hydroxyapatite doped with Tb3+ or Eu3+ ions (SrFHAp:Ln) was successfully synthesized via an efficient and facile hydrothermal process using ethylene diamine tetraacetic acid disodium (Na2EDTA) as the chelating ligand. The as-prepared SrFHAp:Ln product was used as a drug carrier to investigate the drug storage and release properties using ibuprofen (IBU) as a model drug. X-Ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), energy-dispersive X-ray spectrum (EDS), X-ray photoelectron spectra (XPS), fourier transform infrared spectroscopy (FT-IR), nitrogen adsorption/desorption, and photoluminescence spectra were employed to characterize the samples. The results reveal that the as-prepared fluorine substituted hydroxyapatites exhibit a hierarchical double-broccoli-like morphology. By tuning the pH value, Na2EDTA content, and the reaction time, SrFHAp microstructures with different morphologies and sizes have been achieved. A possible formation process of these samples based on the crystal splitting growth mechanism has also been proposed in detail. Moreover, the photoluminescence (PL) measurements indicate that the as-prepared SrFHAp:Ln samples exhibit the characteristic emissions of Tb3+ and Eu3+ even after the loading of organic drug molecules, suggesting its feasible possibility to be monitored or tracked during the drug release and disease therapy process.

Graphical abstract: Controlled synthesis of luminescent F-substituted strontium hydroxyapatite with hierarchical structures for drug delivery

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Article information


Submitted
25 Sep 2011
Accepted
12 Nov 2011
First published
04 Jan 2012

CrystEngComm, 2012,14, 1744-1752
Article type
Paper

Controlled synthesis of luminescent F-substituted strontium hydroxyapatite with hierarchical structures for drug delivery

N. Niu, D. Wang, S. Huang, C. Li, F. He, S. Gai, X. Li and P. Yang, CrystEngComm, 2012, 14, 1744
DOI: 10.1039/C1CE06265D

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