Issue 1, 2007

Effect of polymer addition on the contact line crystallisation of paracetamol

Abstract

In an evaporating aqueous paracetamol solution, crystallisation of the metastable orthorhombic polymorph can occur at the solution–substrate contact line due to a favourable meniscus geometry and enhanced evaporation rates at the edges. Upon the addition of polymers or other common excipients to these systems, it was found that crystallisation of this form was suppressed. This was attributed to the polymer blocking the nucleation sites at the edge of the meniscus, altering the evaporation rate or disrupting the flow of solution to the edges. These results are in contrast to previous conclusions by other groups suggesting that the addition of certain polymers may aid in the selective crystallisation of the orthorhombic polymorph from solution via the formation of specific interactions.

Graphical abstract: Effect of polymer addition on the contact line crystallisation of paracetamol

Supplementary files

Article information

Article type
Paper
Submitted
19 Sep 2006
Accepted
30 Oct 2006
First published
17 Nov 2006

CrystEngComm, 2007,9, 84-90

Effect of polymer addition on the contact line crystallisation of paracetamol

J. S. Capes and R. E. Cameron, CrystEngComm, 2007, 9, 84 DOI: 10.1039/B613663J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements