Issue 4, 2006
From the journal:

CrystEngComm

Effect of the steric demand and hydrogen bonding capability of additives on the crystal polymorphism of sulfathiazole

Joanne M. Kelleher,a   Simon E. Lawrencea  and  Humphrey A. Moynihan*a  

* Corresponding authors

a Department of Chemistry, University College Cork, Cork, Republic of Ireland
E-mail: h.moynihan@ucc.ie
Fax: +353 21 274097
Tel: +353 21 4902488

Abstract

The N-acylsulfathiazole deriviatives 2, 3 and 4, the polymeric N-acylsulfathiazole 6 and the phenolic sulfathiazole analogue 7 were prepared and were found to promote crystallization of form I sulfathiazole from water with inhibition of forms II, III and IV; suggesting that the mode of action of the additives may involve other factors in addition to compatibility with the hydrogen-bonding structure of the various forms.

Graphical abstract: Effect of the steric demand and hydrogen bonding capability of additives on the crystal polymorphism of sulfathiazole

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Article information

DOI
https://doi.org/10.1039/B516716G
Article type
Paper
Submitted
28 Nov 2005
Accepted
16 Mar 2006
First published
23 Mar 2006

CrystEngComm, 2006,8, 327-332

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Effect of the steric demand and hydrogen bonding capability of additives on the crystal polymorphism of sulfathiazole

J. M. Kelleher, S. E. Lawrence and H. A. Moynihan, CrystEngComm, 2006, 8, 327 DOI: 10.1039/B516716G

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