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Issue 3, 2006
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Organic fluorine as crystal engineering tool: Evidence from packing features in fluorine substituted isoquinolines

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Abstract

The crystal structures of six newly synthesized compounds, based on the molecular motif, 6-methoxy 1,2-diphenyl-1,2,3,4-tetrahydroisoquinoline, with different fluoro substitution in 1-phenyl and/or 2-phenyl ring(s) have been reported. Structure determination at 100.0(2) K ensures the accuracy of the evaluation of intermolecular interactions involving F and H atoms. These structures display different packing features by generating molecular motifs via C–F⋯F, C–H⋯F and C–H⋯O interactions in the crystal lattice. The changes in both conformational features and in the intra- and intermolecular interactions involving fluorine provide significant inputs for understanding packing features associated with organic fluorine.

Graphical abstract: Organic fluorine as crystal engineering tool: Evidence from packing features in fluorine substituted isoquinolines

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Publication details

The article was received on 24 Nov 2005, accepted on 20 Feb 2006 and first published on 03 Mar 2006


Article type: Paper
DOI: 10.1039/B516670E
Citation: CrystEngComm, 2006,8, 265-274
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    Organic fluorine as crystal engineering tool: Evidence from packing features in fluorine substituted isoquinolines

    A. R. Choudhury and T. N. G. Row, CrystEngComm, 2006, 8, 265
    DOI: 10.1039/B516670E

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