Issue 56, 2021
From the journal:

Chemical Communications

Polymer nanoparticles regulate macrophage repolarization for antitumor treatment†

Xuancheng Fu,ab   Jiamu Yu,c   Anran Yuan,d   Libing Liu, ORCID logo *ab   Hao Zhao, ORCID logo a   Yiming Huang, ORCID logo a   Song Shen, ORCID logo d   Fengting Lv ORCID logo a  and  Shu Wang ORCID logo ab  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: liulibing@iccas.ac.cn

b College of Chemistry, University of Chinese Academy of Sciences, Beijing 100049, P. R. China

c The Experimental High School Attached to Beijing Normal University, Beijing 100032, P. R. China

d School of Pharmaceutical Science, Jiangsu University, Zhenjiang, P. R. China

Abstract

We demonstrate an intrinsic antitumor effect of polymer nanoparticles (P-NPs), which could re-program tumor-associated macrophages to pro-inflammatory phenotype. The intrinsic effect of P-NPs on macrophage repolarization and its combination with other therapies provide new ideas for drug delivery, macrophage regulation and immunotherapy in cancer treatment.

Graphical abstract: Polymer nanoparticles regulate macrophage repolarization for antitumor treatment

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Article information

DOI
https://doi.org/10.1039/D1CC02678J
Article type
Communication
Submitted
22 May 2021
Accepted
08 Jun 2021
First published
10 Jun 2021

Chem. Commun., 2021,57, 6919-6922

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Polymer nanoparticles regulate macrophage repolarization for antitumor treatment

X. Fu, J. Yu, A. Yuan, L. Liu, H. Zhao, Y. Huang, S. Shen, F. Lv and S. Wang, Chem. Commun., 2021, 57, 6919 DOI: 10.1039/D1CC02678J

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