Issue 53, 2021

Selective primary aniline synthesis through supported Pd-catalyzed acceptorless dehydrogenative aromatization by utilizing hydrazine

Abstract

By utilizing hydrazine (N2H4) as the nitrogen source in the presence of a hydroxyapatite-supported Pd nanoparticle catalyst (Pd/HAP), various primary anilines can be selectively synthesized from cyclohexanones via acceptorless dehydrogenative aromatization. The strong nucleophilicity of N2H4 and the stability of the hydrazone intermediates can effectively suppress the formation of the undesired secondary aniline byproducts.

Graphical abstract: Selective primary aniline synthesis through supported Pd-catalyzed acceptorless dehydrogenative aromatization by utilizing hydrazine

Supplementary files

Article information

Article type
Communication
Submitted
30 Mar 2021
Accepted
01 Jun 2021
First published
01 Jun 2021

Chem. Commun., 2021,57, 6530-6533

Selective primary aniline synthesis through supported Pd-catalyzed acceptorless dehydrogenative aromatization by utilizing hydrazine

W. Lin, T. Yatabe and K. Yamaguchi, Chem. Commun., 2021, 57, 6530 DOI: 10.1039/D1CC01686E

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