Jump to main content
Jump to site search
SCHEDULED MAINTENANCE Close the message box

Maintenance work is planned for Monday 16 August 2021 from 07:00 to 23:59 (BST).

Website performance may be temporarily affected and you may not be able to access some PDFs or images. If this does happen, refreshing your web browser should resolve the issue. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 39, 2021

Novel N-transfer reagent for converting α-amino acid derivatives to α-diazo compounds

Author affiliations

Abstract

A novel universal N-transfer reagent for direct and effective transformation of α-amino ketones, acetamides, and esters to the corresponding α-diazo products under mild basic conditions has been developed. This one-step synthetic approach not only allows for generation of α-substituted-α-diazo carbonyl compounds from α-amino acid derivatives but also permits preparation of α-diazo dipeptides from N-terminal dipeptides (32 examples, up to 91%).

Graphical abstract: Novel N-transfer reagent for converting α-amino acid derivatives to α-diazo compounds

Supplementary files

Article information


Submitted
09 Mar 2021
Accepted
12 Apr 2021
First published
12 Apr 2021

Chem. Commun., 2021,57, 4839-4842
Article type
Communication

Novel N-transfer reagent for converting α-amino acid derivatives to α-diazo compounds

G. Lu, T. Huang, H. Hsueh, S. Yang, T. Cho and H. Chou, Chem. Commun., 2021, 57, 4839 DOI: 10.1039/D1CC01285A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements