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Issue 32, 2021

The primary dipole of flipper probes

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Despite their growing popularity in biology to image membrane tension, central design principles of flipper probes have never been validated. Here we report that upon deletion of their primary dipole, from electron-poor and electron-rich dithienothiophenes, absorptions blue-shift, lifetimes shorten dramatically, and mechanosensitivity in cells vanishes not partially, but completely.

Graphical abstract: The primary dipole of flipper probes

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Article information

15 Feb 2021
10 Mar 2021
First published
23 Mar 2021

This article is Open Access

Chem. Commun., 2021,57, 3913-3916
Article type

The primary dipole of flipper probes

J. García-Calvo, J. López-Andarias, N. Sakai and S. Matile, Chem. Commun., 2021, 57, 3913 DOI: 10.1039/D1CC00860A

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