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Issue 32, 2021

The primary dipole of flipper probes

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Abstract

Despite their growing popularity in biology to image membrane tension, central design principles of flipper probes have never been validated. Here we report that upon deletion of their primary dipole, from electron-poor and electron-rich dithienothiophenes, absorptions blue-shift, lifetimes shorten dramatically, and mechanosensitivity in cells vanishes not partially, but completely.

Graphical abstract: The primary dipole of flipper probes

Supplementary files

Article information


Submitted
15 Feb 2021
Accepted
10 Mar 2021
First published
23 Mar 2021

This article is Open Access

Chem. Commun., 2021,57, 3913-3916
Article type
Communication

The primary dipole of flipper probes

J. García-Calvo, J. López-Andarias, N. Sakai and S. Matile, Chem. Commun., 2021, 57, 3913 DOI: 10.1039/D1CC00860A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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