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Issue 32, 2021
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Dual-MicroRNA-regulation of singlet oxygen generation by a DNA-tetrahedron-based molecular logic device

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Abstract

Endogenous miRNA expression patterns are extremely cell-type-specific, thereby offering high prediction accuracy for different cell identities. Here, a DNA-tetrahedron-based “AND” logic gate is utilized as a molecular device that recognizes dual-miRNA inputs through strand hybridization to activate a computation cascade that produces controlled singlet oxygen in live cells, resulting in the death of the target cell.

Graphical abstract: Dual-MicroRNA-regulation of singlet oxygen generation by a DNA-tetrahedron-based molecular logic device

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Article information


Submitted
12 Feb 2021
Accepted
11 Mar 2021
First published
11 Mar 2021

Chem. Commun., 2021,57, 3873-3876
Article type
Communication

Dual-MicroRNA-regulation of singlet oxygen generation by a DNA-tetrahedron-based molecular logic device

Q. Lin, S. Cai, B. Zhou, K. Wang, L. Jian and J. Huang, Chem. Commun., 2021, 57, 3873
DOI: 10.1039/D1CC00818H

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