Issue 53, 2021
From the journal:

Chemical Communications

A ratiometric electrochemical sensor for selectively monitoring monoamine oxidase A in the live brain†

Chuanping Zhang,‡a   Chenxiao Tang,‡a   Yuxiao Mei,a   Limin Zhang, ORCID logo a   Anwei Zhu ORCID logo *a  and  Yang Tian ORCID logo *a  

* Corresponding authors

a School of Chemistry and Molecular Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China
E-mail: ytian@chem.ecnu.edu.cn, awzhu@chem.ecnu.edu.cn

Abstract

Herein, an electrochemical method for selectively sensing and accurately quantifying monoamine oxidase A (MAO-A) in the cortex and thalamus of a live mouse brain was reported. Using this tool, it was found that MAO-A increased Ca2+ entry into neurons via the TPRM2 channel in the live mouse brain of an AD model.

Graphical abstract: A ratiometric electrochemical sensor for selectively monitoring monoamine oxidase A in the live brain

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Article information

DOI
https://doi.org/10.1039/D1CC00787D
Article type
Communication
Submitted
10 Feb 2021
Accepted
01 Jun 2021
First published
02 Jun 2021

Chem. Commun., 2021,57, 6487-6490

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A ratiometric electrochemical sensor for selectively monitoring monoamine oxidase A in the live brain

C. Zhang, C. Tang, Y. Mei, L. Zhang, A. Zhu and Y. Tian, Chem. Commun., 2021, 57, 6487 DOI: 10.1039/D1CC00787D

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