Issue 20, 2021
From the journal:

Chemical Communications

Metal-responsive reversible binding of triplex-forming oligonucleotides with 5-hydroxyuracil nucleobases†

Kotaro Nishiyama, ORCID logo a   Keita Mori, ORCID logo a   Yusuke Takezawa ORCID logo a  and  Mitsuhiko Shionoya ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
E-mail: shionoya@chem.s.u-tokyo.ac.jp

Abstract

Metal-responsive triplex-forming oligonucleotides (TFOs) were synthesised by incorporating 5-hydroxyuracil (UOH) nucleobases as metal recognition sites. Binding of the UOH-containing TFO to the target natural DNA duplexes was reversibly regulated by the addition and removal of GdIII ions under isothermal conditions.

Graphical abstract: Metal-responsive reversible binding of triplex-forming oligonucleotides with 5-hydroxyuracil nucleobases

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Article information

DOI
https://doi.org/10.1039/D1CC00553G
Article type
Communication
Submitted
30 Jan 2021
Accepted
15 Feb 2021
First published
16 Feb 2021

Chem. Commun., 2021,57, 2487-2490

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Metal-responsive reversible binding of triplex-forming oligonucleotides with 5-hydroxyuracil nucleobases

K. Nishiyama, K. Mori, Y. Takezawa and M. Shionoya, Chem. Commun., 2021, 57, 2487 DOI: 10.1039/D1CC00553G

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