Accelerated DNA tetrahedron-based molecular beacon for efficient microRNA imaging in living cells

Chao Xing; Ziyi Chen; Yuhong Lin; Min Wang; Xin Xu; Junduan Dai; Jun Wang; Chunhua Lu

doi:10.1039/D0CC08172H

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Accelerated DNA tetrahedron-based molecular beacon for efficient microRNA imaging in living cells†

Chao Xing,

*^a Ziyi Chen,^b Yuhong Lin,^b Min Wang,^b Xin Xu,^b Junduan Dai,^b Jun Wang*^a and Chunhua Lu

*^b

Author affiliations

* Corresponding authors

^a Fujian Key Laboratory of Functional Marine Sensing Materials, Center for Advanced Marine Materials and Smart Sensors, Minjiang University, Fuzhou 350108, P. R. China
E-mail: chaoxing@mju.edu.cn, wangjun2@mju.edu.cn

^b MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian College of Chemistry, Fuzhou University, Fuzhou 350116, P. R. China
E-mail: chunhualu@fzu.edu.cn

Abstract

Herein, we develop an accelerated DNA tetrahedron based molecular beacon for efficient detection and imaging of miRNA in living cells. Our study provides an improved strategy for fluorescence amplified RNA imaging in early clinical diagnosis.

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Article information

DOI: https://doi.org/10.1039/D0CC08172H
Article type: Communication
Submitted: 16 Dec 2020
Accepted: 20 Feb 2021
First published: 23 Feb 2021

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Chem. Commun., 2021,57, 3251-3254

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Accelerated DNA tetrahedron-based molecular beacon for efficient microRNA imaging in living cells

C. Xing, Z. Chen, Y. Lin, M. Wang, X. Xu, J. Dai, J. Wang and C. Lu, Chem. Commun., 2021, 57, 3251 DOI: 10.1039/D0CC08172H

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Chemical Communications

Accelerated DNA tetrahedron-based molecular beacon for efficient microRNA imaging in living cells†

Abstract

Supplementary files

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Accelerated DNA tetrahedron-based molecular beacon for efficient microRNA imaging in living cells

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