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Issue 12, 2021
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GALA peptide improves the potency of nanobody–drug conjugates by lipid-induced helix formation

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Abstract

A novel nanobody–drug conjugate (NDC) was constructed by incorporating an amphipathic peptide, GALA, which improved the cytotoxicity by one to two orders of magnitude. Mechanistic studies demonstrate that tethering to lipids induces GALA to form a helix, which dramatically enhances endocytosis. Our work provides a general strategy not only for improving the anti-cancer efficacy of protein-drug conjugates but also for increasing the efficiency of other types of endocytosis-dependent cell delivery.

Graphical abstract: GALA peptide improves the potency of nanobody–drug conjugates by lipid-induced helix formation

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Article information


Submitted
25 Nov 2020
Accepted
15 Jan 2021
First published
29 Jan 2021

Chem. Commun., 2021,57, 1434-1437
Article type
Communication

GALA peptide improves the potency of nanobody–drug conjugates by lipid-induced helix formation

Y. J. Chen, Q. W. Deng, L. Wang, X. C. Guo, J. Y. Yang, T. Li, Z. Xu, H. C. Lee and Y. J. Zhao, Chem. Commun., 2021, 57, 1434
DOI: 10.1039/D0CC07706B

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