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Issue 72, 2020
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Catalytic mutual multicomponent reaction: facile access to α-trifluoromethylthiolated ketones

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Abstract

A multicomponent catalytic reaction between ketones, Morita–Baylis–Hillman (MBH) carbonates and trifluoromethylthiolating agents is devised for straightforwardly accessing two products, α-trifluoromethylthiolated ketones and α-methylene β-amino esters in a one pot fashion. Particularly noteworthy is that the trifluoromethylthiolating reagent is employed as both the nitrogen and SCF3 source initiated by DABCO. This mild one pot strategy enjoys atom- and step-economic attractiveness, for direct introduction of an SCF3 group onto a variety of acyclic ketones, which have been considered as less effective and less developed substrates.

Graphical abstract: Catalytic mutual multicomponent reaction: facile access to α-trifluoromethylthiolated ketones

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Article information


Submitted
01 Jul 2020
Accepted
22 Jul 2020
First published
24 Jul 2020

Chem. Commun., 2020,56, 10552-10555
Article type
Communication

Catalytic mutual multicomponent reaction: facile access to α-trifluoromethylthiolated ketones

M. Y. Jin, X. Gu, M. Deng, C. Wang and J. (. Wang, Chem. Commun., 2020, 56, 10552
DOI: 10.1039/D0CC04555A

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