Issue 82, 2020

Selective hydrogenation of primary amides and cyclic di-peptides under Ru-catalysis

Abstract

A ruthenium(II)-catalyzed selective hydrogenation of challenging primary amides and cyclic di-peptides to their corresponding primary alcohols and amino alcohols, respectively, is reported. The hydrogenation reaction operates under mild and eco-benign conditions and can be scaled-up.

Graphical abstract: Selective hydrogenation of primary amides and cyclic di-peptides under Ru-catalysis

Supplementary files

Article information

Article type
Communication
Submitted
01 Jul 2020
Accepted
26 Aug 2020
First published
26 Aug 2020

Chem. Commun., 2020,56, 12411-12414

Selective hydrogenation of primary amides and cyclic di-peptides under Ru-catalysis

M. Subaramanian, G. Sivakumar, J. K. Babu and E. Balaraman, Chem. Commun., 2020, 56, 12411 DOI: 10.1039/D0CC04550K

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