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Issue 77, 2020
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Structural conversion of human islet amyloid polypeptide aggregates under an electric field

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Abstract

Electric fields (EFs) in biological systems are well known, and their presence implies the activity of protein ion channels and pumps in various cells. The aggregation of islet amyloid polypeptides (IAPP) was recently found in human brain tissue, and this was related to the electrical activity of neurons and caused neuronal loss. However, the association between amyloid formation and the electric field is still unknown. Herein a direct method to stimulate the formation of the hIAPP peptide under an EF is reported.

Graphical abstract: Structural conversion of human islet amyloid polypeptide aggregates under an electric field

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Article information


Submitted
28 Jun 2020
Accepted
10 Aug 2020
First published
11 Aug 2020

Chem. Commun., 2020,56, 11497-11500
Article type
Communication

Structural conversion of human islet amyloid polypeptide aggregates under an electric field

Y. Song, R. Wu, Y. Wang, L. Liu and M. Dong, Chem. Commun., 2020, 56, 11497
DOI: 10.1039/D0CC04466K

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