Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres

Min Zhu; Yanyan Yu; Junfeng Zhu; Yao Zhou; Gaoxing Su; Hongyan Zhu; Yong Chen; Mingkai Liu

doi:10.1039/D0CC03425H

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Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres†

Min Zhu,^a Yanyan Yu,

*^a Junfeng Zhu,^a Yao Zhou,^a Gaoxing Su,

^a Hongyan Zhu,

^a Yong Chen^a and Mingkai Liu

*^bc

Author affiliations

* Corresponding authors

^a School of Pharmacy, Nantong University, Nantong, Jiangsu 226001, China
E-mail: yuyanyan@ntu.edu.cn

^b School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China
E-mail: liumingkai@jsnu.edu.cn

^c The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA
E-mail: liu.mingkai@bme.gatech.edu

Abstract

Toehold exchange spherical nucleic acids (TESNA) modulated on molybdenum disulfide (MoS₂) acanthospheres were proposed for the discrimination of single nucleotide variants (SNVs). We rationally optimized the probe by making a trade-off between the discrimination factor (DF) and hybridization ratio (χ). The TESNA platform can distinguish SNVs with significantly improved sensitivity and specificity.

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Article information

DOI: https://doi.org/10.1039/D0CC03425H
Article type: Communication
Submitted: 13 May 2020
Accepted: 29 Jun 2020
First published: 29 Jun 2020

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Chem. Commun., 2020,56, 8599-8602

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Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres

M. Zhu, Y. Yu, J. Zhu, Y. Zhou, G. Su, H. Zhu, Y. Chen and M. Liu, Chem. Commun., 2020, 56, 8599 DOI: 10.1039/D0CC03425H

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Chemical Communications

Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres†

Abstract

Supplementary files

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Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres

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