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Issue 59, 2020
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Unique cellular interaction of macrophage-targeted liposomes potentiates anti-inflammatory activity

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Abstract

Nanomedicines that suppress macrophage-mediated chronic inflammation are important therapeutics for many inflammatory diseases. The small-sized (<100 nm) apoptotic-cell-mimetic macrophage-targeted liposomes served as a long-lasting immunosuppressive agent through preferential association with CD300a receptor, unlike larger liposomes, enabling the amelioration of hepatic inflammation in mice.

Graphical abstract: Unique cellular interaction of macrophage-targeted liposomes potentiates anti-inflammatory activity

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Article information


Submitted
08 May 2020
Accepted
16 Jun 2020
First published
16 Jun 2020

Chem. Commun., 2020,56, 8253-8256
Article type
Communication

Unique cellular interaction of macrophage-targeted liposomes potentiates anti-inflammatory activity

R. Toita, E. Shimizu and J. Kang, Chem. Commun., 2020, 56, 8253
DOI: 10.1039/D0CC03320K

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