A macrocycle directed total synthesis of di-O-methylendiandrin A†
John D.
Gorden 
a
and
Bradley L.
Merner
*a
a
and
Bradley L.
Merner
*a
Abstract
The total synthesis of the lignan-based cyclobutane di-O-methylendiandrin A has been achieved using diastereoselective, vicinal alkylation and transannular McMurry reactions of a macrocyclic 1,4-diketone as key transformations for establishing relative stereochemistry and furnishing the strained 4-membered ring of the natural product.
- This article is part of the themed collections: 2020 Emerging Investigators and Natural product synthesis
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