Issue 51, 2020
From the journal:

Chemical Communications

Cell organelle targeting of near-infrared croconaine dye controls photothermal outcome†

Ying Wen,ab   Hannah H. McGarraugh, ORCID logo a   Cynthia L. Schreiber ORCID logo a  and  Bradley D. Smith ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556, USA
E-mail: smith.115@nd.edu

b Institute of Molecular Science, Shanxi University, Taiyuan 030006, China

Abstract

Near-infrared croconaine–peptide conjugates that target the cell nucleus promote photothermal induced cell death. In contrast, a croconaine–morpholine conjugate that targets the cell lysosomes promotes lysosome permeabilization without measurable cell phototoxicity.

Graphical abstract: Cell organelle targeting of near-infrared croconaine dye controls photothermal outcome

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Article information

DOI
https://doi.org/10.1039/D0CC02612C
Article type
Communication
Submitted
10 Apr 2020
Accepted
15 May 2020
First published
15 May 2020

Chem. Commun., 2020,56, 6977-6980

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Cell organelle targeting of near-infrared croconaine dye controls photothermal outcome

Y. Wen, H. H. McGarraugh, C. L. Schreiber and B. D. Smith, Chem. Commun., 2020, 56, 6977 DOI: 10.1039/D0CC02612C

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