Light-induced molecular rotation triggers on-demand release from liposomes

Laís Ribovski; Qihui Zhou; Jiawen Chen; Ben L. Feringa; Patrick van Rijn; Inge S. Zuhorn

doi:10.1039/D0CC02499F

Light-induced molecular rotation triggers on-demand release from liposomes†

Laís Ribovski,

^ab Qihui Zhou,

^c Jiawen Chen,^d Ben L. Feringa,

^d Patrick van Rijn

*^a and Inge S. Zuhorn

*^a

Author affiliations

* Corresponding authors

^a University of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands
E-mail: p.van.rijn@umcg.nl, i.zuhorn@umcg.nl

^b Nanomedicine and Nanotoxicology Group, Physics Institute of São Carlos, University of São Paulo, CP 369, 13560-970 São Carlos, SP, Brazil

^c Institute for Translational Medicine, Department of Periodontology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266021, China

^d Center for Systems Chemistry, Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747AG Groningen, The Netherlands

Abstract

Controllable molecular release from delivery vehicles is essential to successfully reduce drug toxicity and improve therapeutic efficacy. Light-powered hydrophobic molecular motors were therefore incorporated in liposomes to use molecular rotation to facilitate on-demand release. The extent of the release was precisely controlled by irradiation times, providing a simple yet sophisticated responsive molecular nanocarrier.

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Article information

DOI: https://doi.org/10.1039/D0CC02499F
Article type: Communication
Submitted: 07 Apr 2020
Accepted: 29 Jun 2020
First published: 01 Jul 2020
This article is Open Access

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Chem. Commun., 2020,56, 8774-8777

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Light-induced molecular rotation triggers on-demand release from liposomes

L. Ribovski, Q. Zhou, J. Chen, B. L. Feringa, P. van Rijn and I. S. Zuhorn, Chem. Commun., 2020, 56, 8774 DOI: 10.1039/D0CC02499F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Chemical Communications

Light-induced molecular rotation triggers on-demand release from liposomes†

Abstract

Supplementary files

Article information

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Light-induced molecular rotation triggers on-demand release from liposomes

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